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[보도자료] BRIC 한국을 빛내는 사람들 ( 2017-02-22 15:32:22 )  
link 1https://www.ibric.org:442/myboard/read.php?Board=hbs_treatise&id=48468&idauthorid=6665&Page=7&BackLink=L2hhbmJpdHNhL3RyZWF0aXNlX2luZGV4LnBocD9QYWdlPTc=

BRIC한국을 빛내는 사람들

정은지(Eunji Cheong)
The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Go Eun Ha1,*, Jaekwang Lee2,*, Hankyul Kwak1, Kiyeong Song1, Jea Kwon2, Soon-Young Jung2, Joohyeon Hong1, Gyeong-Eon Chang1, Eun Mi Hwang3, Hee-Sup Shin4, C. Justin Lee2 & Eunji Cheong1

1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea. 2 Center for Neural Science, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. 3 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. 4 Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34141, Republic of Korea.
* These authors contributed equally to this work.

Correspondence to Eunji Cheong

Neuronal firing patterns, which are crucial for determining the nature of encoded information, have been widely studied; however, the molecular identity and cellular mechanisms of spike-frequency adaptation are still not fully understood. Here we show that spike-frequency adaptation in thalamocortical (TC) neurons is mediated by the Ca2+-activated Cl- channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in TC neurons results in significantly reduced spike-frequency adaptation along with increased tonic spiking. Moreover, thalamus-specific knockdown of ANO2 increases visceral pain responses. These results indicate that ANO2 contributes to reductions in spike generation in highly activated TC neurons and thereby restricts persistent information transmission.

- 형식: Research article
- 게재일: 2016년 12월 (BRIC 등록일 2016.12.20)
- 연구진: 국내연구진 태극기
- 분야: Neuroscience


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