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[보도자료] BRIC 한국을 빛내는 사람들 ( 2017-02-22 15:32:22 )  
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link 1https://www.ibric.org:442/myboard/read.php?Board=hbs_treatise&id=48468&idauthorid=6665&Page=7&BackLink=L2hhbmJpdHNhL3RyZWF0aXNlX2luZGV4LnBocD9QYWdlPTc=

BRIC한국을 빛내는 사람들

정은지
정은지(Eunji Cheong)
연세대학교
   
The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Go Eun Ha1,*, Jaekwang Lee2,*, Hankyul Kwak1, Kiyeong Song1, Jea Kwon2, Soon-Young Jung2, Joohyeon Hong1, Gyeong-Eon Chang1, Eun Mi Hwang3, Hee-Sup Shin4, C. Justin Lee2 & Eunji Cheong1

1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea. 2 Center for Neural Science, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. 3 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. 4 Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34141, Republic of Korea.
* These authors contributed equally to this work.

Correspondence to Eunji Cheong

Abstract
Neuronal firing patterns, which are crucial for determining the nature of encoded information, have been widely studied; however, the molecular identity and cellular mechanisms of spike-frequency adaptation are still not fully understood. Here we show that spike-frequency adaptation in thalamocortical (TC) neurons is mediated by the Ca2+-activated Cl- channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in TC neurons results in significantly reduced spike-frequency adaptation along with increased tonic spiking. Moreover, thalamus-specific knockdown of ANO2 increases visceral pain responses. These results indicate that ANO2 contributes to reductions in spike generation in highly activated TC neurons and thereby restricts persistent information transmission.

논문정보
- 형식: Research article
- 게재일: 2016년 12월 (BRIC 등록일 2016.12.20)
- 연구진: 국내연구진 태극기
- 분야: Neuroscience

 



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